The Babette Dictionary

What does that mean?

Breast cancer comes with a language nobody teaches you. Search the thing your doctor said, the phrase in your pathology report or the nickname somebody dropped in the infusion room.

You don't need to know the medical term. We'll help with that part.

Search what you heard

Try normal-person language: “cancer in my armpit,” “chemo before surgery,” “radiation mapping,” “estrogen positive.”

Look it up

The words they keep using, in words you actually understand.

AC chemotherapy

Doxorubicin + cyclophosphamide · Adriamycin + Cytoxan
Drugs + treatment
The medical version

AC is a breast-cancer chemotherapy regimen containing doxorubicin and cyclophosphamide.

Babette translates

The A is Adriamycin, another name for doxorubicin. The C is cyclophosphamide. If someone says you're “doing AC,” they're talking about this combination.

Why you're hearing this: AC may be used as part of chemotherapy before or after breast surgery.

Adjuvant therapy

Treatment after surgery
Treatment
The medical version

Treatment given after the primary treatment, often surgery, to reduce the risk of cancer returning.

Babette translates

Treatment that comes after the main event—usually surgery—to deal with cancer cells that could remain or lower the chance of the cancer coming back.

Don't confuse it with: Neoadjuvant therapy, which happens before surgery.

Aesthetic flat closure

AFC · Going flat · Flat closure
Surgery
The medical version

A surgical approach after mastectomy in which excess skin, fat and tissue are arranged or removed to create a smooth, flat chest contour rather than a breast mound.

Babette translates

You can have a mastectomy and choose not to reconstruct a breast shape. “Going flat” is a real surgical choice—not a failure to finish reconstruction.

Good question to ask: “If I want to be flat, what will you do during surgery to create the chest contour?”

Amplification

Gene amplification
Pathology + genetics
The medical version

An increase in the number of copies of a particular gene within a cell.

Babette translates

The cancer cells have extra copies of a gene. In breast cancer, you may hear this when your team is figuring out HER2 status.

Aromatase inhibitor

AI · Anastrozole · Letrozole · Exemestane
Drugs + treatment
The medical version

A class of endocrine therapy that lowers estrogen production by blocking the aromatase enzyme.

Babette translates

If estrogen helps your cancer grow, this is one way doctors can turn down the body's estrogen supply.

Axilla

Underarm · Armpit
Anatomy
The medical version

The anatomical term for the underarm area. Several groups of lymph nodes important in breast-cancer staging are located there.

Babette translates

Your armpit. Seriously. That's the fancy word.

Axillary lymph node dissection

ALND · Axillary dissection
Surgery
The medical version

Surgery to remove multiple lymph nodes from the axilla so they can be examined for cancer.

Babette translates

Instead of removing only the first few sentinel nodes, the surgeon removes a larger group of lymph nodes from your underarm.

Why you care: The number of nodes removed and the treatment you've had can affect issues such as lymphedema risk. Ask what is planned for your specific surgery.

BI-RADS

Breast Imaging Reporting and Data System
Imaging
The medical version

A standardized system radiologists use to categorize breast imaging findings and communicate recommended follow-up.

Babette translates

It's a category on your imaging report that helps explain what the radiologist saw and what should happen next.

Important: Your BI-RADS number is not your cancer stage.

Biomarker

Biological marker
Pathology
The medical version

A measurable biological characteristic that can provide information about a cancer, including prognosis or whether a particular treatment may be useful.

Babette translates

A clue your doctors can measure. ER, PR and HER2 are examples you'll hear about a lot because they can help shape treatment.

Biopsy

Tissue sample
Diagnosis
The medical version

A procedure that removes cells or tissue so a pathologist can examine them for disease.

Babette translates

Imaging can show that something looks suspicious. A biopsy gets actual cells or tissue so someone can determine what that thing really is.

BRCA1 + BRCA2

Hereditary cancer genes
Genetics
The medical version

Genes involved in DNA repair. Certain inherited harmful variants in BRCA1 or BRCA2 increase the risk of breast and other cancers.

Babette translates

Everyone has BRCA genes. The question is whether you inherited a harmful change in one of them that changes your cancer risk.

Breast density

Dense breasts
Imaging
The medical version

A description of the relative amount of fibroglandular tissue and fatty tissue visible on a mammogram.

Babette translates

Dense breasts have more glandular and fibrous tissue relative to fat. Density can make mammograms harder to read and is also one factor considered in breast-cancer risk.

Calcifications

Microcalcifications · Calcium deposits
Imaging
The medical version

Calcium deposits visible on breast imaging. Many patterns are benign, while some patterns may require additional evaluation.

Babette translates

Tiny calcium spots on a mammogram. Seeing them does not automatically mean cancer. The pattern, size and arrangement are part of what the radiologist evaluates.

Chemotherapy

Chemo
Treatment
The medical version

Treatment using anticancer drugs that can travel through the body to destroy cancer cells or interfere with their growth.

Babette translates

Cancer-fighting medicine that works throughout the body, rather than treating only the breast or one specific spot.

Scalp cooling

Cold cap · Cold capping
Side effects
The medical version

Cooling of the scalp before, during and sometimes after chemotherapy to reduce blood flow to hair follicles and help reduce chemotherapy-related hair loss in some people.

Babette translates

The very cold cap you've probably heard about. The goal is to help preserve some hair during certain chemotherapy treatments. It doesn't work the same way for everyone or every regimen.

Axillary web syndrome

Cording · AWS
Recovery
The medical version

A postoperative condition in which tight, cord-like structures can develop under the skin of the axilla and sometimes extend down the arm.

Babette translates

That tight string or cord you can sometimes see or feel in your armpit or arm after breast or lymph-node surgery has a name. Tell your care team; rehabilitation or physical therapy may help.

DCIS

Ductal carcinoma in situ
Diagnosis
The medical version

Abnormal cells confined to the breast ducts that have not invaded surrounding breast tissue.

Babette translates

The abnormal cells are inside a milk duct, but they haven't broken through the duct wall into the surrounding breast tissue.

You may hear: DCIS described as noninvasive breast cancer or stage 0.

Diagnostic mammogram

Additional mammogram views
Imaging
The medical version

Mammography used to evaluate a breast symptom or an area of concern identified on screening.

Babette translates

This isn't the routine screening version. They're taking a closer look at a specific area because there's something they want to understand better.

Doxorubicin

Adriamycin · “Red Devil” · Adria
Chemotherapy drug
The medical version

Doxorubicin is an anthracycline chemotherapy drug used in the treatment of several cancers, including breast cancer.

Babette translates

This is the bright red chemotherapy drug people sometimes call the “Red Devil.” That's a nickname. The actual drug is doxorubicin, also known as Adriamycin.

Why you're hearing this: Doxorubicin can be part of regimens such as AC and AC-T. Your oncology team will discuss the side effects and monitoring that apply to your treatment plan.

Endocrine therapy

Hormone therapy · Hormonal therapy
Treatment
The medical version

Treatment that blocks hormones or lowers hormone levels to interfere with the growth of hormone receptor-positive cancer.

Babette translates

If hormones such as estrogen are helping the cancer grow, endocrine therapy tries to interrupt that relationship.

ER / ER+

Estrogen receptor · Estrogen receptor-positive
Pathology
The medical version

A biomarker indicating whether breast-cancer cells contain receptors for estrogen.

Babette translates

They're checking whether estrogen can act like a growth signal for the cancer. If the tumor is ER-positive, treatments that interfere with estrogen may be part of your plan.

FISH

Fluorescence in situ hybridization
Pathology
The medical version

A laboratory technique that can evaluate gene changes such as HER2 gene amplification in tumor tissue.

Babette translates

If someone says they're doing a “FISH test,” nobody is testing an actual fish. It's a lab test that can help clarify HER2 status by looking at copies of the HER2 gene.

Germline mutation

Inherited genetic variant
Genetics
The medical version

A genetic change present in the egg or sperm and therefore present throughout the body; it can potentially be passed from parent to child.

Babette translates

This is the kind of genetic change you can be born with and potentially pass through a family. It is different from a mutation found only in the tumor.

Grade

Tumor grade · Nottingham grade
Pathology
The medical version

A microscopic assessment of how much cancer cells differ from normal breast cells. Breast tumor grade commonly incorporates gland formation, nuclear features and mitotic activity.

Babette translates

Grade is about what the cancer looks like under the microscope and features related to how it's growing. It is not the same thing as stage.

Wait. Stage and grade aren't the same thing? Nope. Stage describes a different part of the cancer picture.

HER2

Human epidermal growth factor receptor 2
Pathology
The medical version

HER2 is a growth-related protein. Breast cancers are evaluated for HER2 because the result can help classify the cancer and guide treatment.

Babette translates

Your team is measuring a growth-related target on the cancer. That result matters because certain treatments are designed to target HER2.

You may see: IHC scores, FISH/ISH results, HER2-positive, HER2-negative, HER2-low or other treatment-relevant HER2 expression language. Ask your oncologist what your specific result means for you.

IHC

Immunohistochemistry
Pathology
The medical version

A laboratory method using antibodies to detect specific proteins in tissue.

Babette translates

A special lab stain that helps the pathologist see whether certain proteins are present in the tumor—and sometimes how strongly they're showing up.

Invasive

Infiltrating
Diagnosis
The medical version

Cancer is called invasive when it has grown beyond the structure where it began and into surrounding breast tissue.

Babette translates

This word sounds terrifying. What it tells you is that the cancer has moved into nearby breast tissue. It does not automatically mean the cancer has spread to a distant part of your body.

Don't confuse it with: Metastatic breast cancer.

Invasive ductal carcinoma

IDC · Infiltrating ductal carcinoma
Diagnosis
The medical version

Breast cancer that began in a duct and has grown into surrounding breast tissue.

Babette translates

It started in a milk duct and crossed beyond that duct into nearby breast tissue. Again: “invasive” does not automatically mean distant spread.

Invasive lobular carcinoma

ILC
Diagnosis
The medical version

An invasive breast cancer arising from cells associated with the breast lobules.

Babette translates

This breast cancer is associated with the milk-producing lobules rather than being classified as ductal.

Ki-67

Proliferation marker
Pathology
The medical version

A protein associated with cell division that can be measured to estimate the proportion of tumor cells actively proliferating.

Babette translates

One clue about how many tumor cells appear to be actively dividing. It's a piece of the picture—not a diagnosis by itself.

LCIS

Lobular carcinoma in situ
Pathology
The medical version

A proliferation of abnormal cells within breast lobules that is associated with an increased risk of developing invasive breast cancer.

Babette translates

Despite the alarming name, LCIS behaves differently from invasive breast cancer. It's an important finding because it tells your team something about future breast-cancer risk.

Lymph node

Node-positive · Node-negative
Staging
The medical version

Small immune-system structures that filter lymphatic fluid. Nearby lymph nodes may be examined for breast-cancer cells.

Babette translates

Your team may check the lymph nodes near the breast because they can provide important information about whether cancer cells have moved beyond the original breast tumor.

Important: Cancer in a nearby lymph node does not, by itself, mean stage IV.

Lymphovascular invasion

LVI
Pathology
The medical version

Cancer cells identified within lymphatic or blood-vessel spaces in or around a tumor.

Babette translates

The pathologist saw cancer cells inside tiny channels that carry lymph or blood. Your team considers this finding alongside the rest of your pathology—not in isolation.

Lymphedema

Lymphatic swelling
Side effects
The medical version

Swelling caused by an accumulation of lymphatic fluid when normal lymph drainage is disrupted.

Babette translates

Breast-cancer surgery or radiation can affect lymph drainage. If you notice new or persistent swelling, heaviness or tightness, tell your care team rather than trying to diagnose it yourself.

Mammogram

Mammography
Imaging
The medical version

A specialized low-dose x-ray examination of breast tissue.

Babette translates

The breast x-ray where each breast is positioned and compressed so the radiologist can look for changes that may need a closer look.

Margins

Surgical margins · Clear margins · Clean margins
Surgery + pathology
The medical version

The edges of tissue removed during surgery. A pathologist examines those edges for cancer cells.

Babette translates

After tissue is removed, the pathologist checks the outer edges. Your team wants to know whether cancer reaches the edge of what was taken out.

Wait. “Negative” can be good? In margin language, a negative margin means cancer was not seen at the cut edge. A positive margin means cancer is at the edge. What margin is considered adequate depends on the clinical situation.

Mastectomy

Breast-removal surgery
Surgery
The medical version

Surgery to remove breast tissue. Different mastectomy techniques remove or preserve different structures depending on the clinical and reconstructive plan.

Babette translates

“Mastectomy” is a category, not one single operation. Ask exactly what your surgeon plans to remove, what may be preserved and what your chest is expected to look like afterward.

Metastatic breast cancer

MBC · Stage IV breast cancer · Distant metastasis
Metastatic
The medical version

Breast cancer that has spread from the breast to a distant part of the body.

Babette translates

This means breast-cancer cells are growing somewhere distant from the breast—such as bone, liver, lung or brain. Cancer in nearby breast tissue or regional lymph nodes is not the same thing as distant metastasis.

Mitotic count

Mitotic rate · Mitoses
Pathology
The medical version

A microscopic assessment of how many cells are visibly undergoing division in a defined area.

Babette translates

The pathologist is literally looking for cells caught in the act of dividing. It's one of the features that can contribute to breast tumor grade.

Breast MRI

Magnetic resonance imaging
Imaging
The medical version

Imaging that uses a magnetic field and radio waves to create detailed pictures of breast tissue.

Babette translates

A detailed breast scan made with magnets and radio waves, not x-rays. Whether you need one depends on why your team is imaging you.

Neoadjuvant therapy

Treatment before surgery
Treatment
The medical version

Cancer treatment given before surgery. Depending on the cancer, this may include chemotherapy, targeted therapy or other systemic treatment.

Babette translates

They're treating the cancer before operating instead of automatically doing surgery first.

A useful question: “Why are we treating before surgery in my case, and what are you hoping to learn or accomplish?”

NED

No evidence of disease
Cancer language
The medical version

A phrase used when current examinations or tests do not detect evidence of cancer.

Babette translates

At this moment, the tests being used aren't showing detectable disease. Ask your team what NED means in the context of your specific diagnosis and follow-up plan.

Peripheral neuropathy

Neuropathy · Tingling/numb hands or feet
Side effects
The medical version

Damage or irritation involving peripheral nerves that can cause numbness, tingling, burning, pain or other sensory changes. Some cancer treatments can cause peripheral neuropathy.

Babette translates

If your fingers or toes start tingling, burning, feeling numb or just feeling wrong during treatment, don't quietly tough it out. Tell your oncology team.

Pegfilgrastim

Neulasta · Udenyca · Fulphila · Nyvepria · Ziextenzo
Supportive medication
The medical version

A long-acting form of granulocyte colony-stimulating factor used to help the bone marrow produce more white blood cells and reduce infection risk associated with chemotherapy-induced neutropenia.

Babette translates

This may be the “white blood cell shot” or “shot after chemo” someone mentioned. It helps your bone marrow make more infection-fighting white blood cells.

You may hear a brand name instead: Neulasta is one, but there are several pegfilgrastim products.

Nuclear grade

Nuclear atypia
Pathology
The medical version

A microscopic assessment of how abnormal the nuclei of tumor cells appear compared with normal cells.

Babette translates

The pathologist is looking closely at the control centers of the cells—the nuclei—and judging how different they look from normal.

Oncotype DX

Recurrence Score · Genomic assay
Genomic testing
The medical version

A genomic assay used in certain breast cancers that analyzes gene activity in tumor tissue and produces a recurrence score that can help inform treatment decisions.

Babette translates

This is a test on the tumor. It is not the same thing as testing whether you inherited a breast-cancer gene. In eligible cancers, the result can help inform decisions about chemotherapy.

Don't confuse: Genomic testing of the tumor with genetic testing for inherited variants.

Palliative care

Supportive symptom care
Supportive care
The medical version

Specialized care focused on relieving symptoms, treatment side effects and other sources of distress associated with serious illness.

Babette translates

Palliative care is about helping you feel and function as well as possible while dealing with serious illness. It is not synonymous with hospice, and it can be provided alongside cancer treatment.

Pathology report

The report everybody expects you to understand
Pathology
The medical version

A report prepared after a pathologist examines cells or tissue. Depending on the specimen, it can contain information about cancer type, grade, biomarkers, margins, lymph nodes and other findings.

Babette translates

This is one of the documents where the details of your cancer start coming together. And yes, it often reads like it was written for everyone except you.

Also: Results may arrive in stages. An addendum can contain additional testing that wasn't ready when the first report appeared.

Port

Implanted port · Port-a-cath
Treatment
The medical version

A small implanted vascular-access device connected to a catheter and placed under the skin, often in the upper chest.

Babette translates

A small device under your skin that gives the infusion team reliable access to a vein without starting a new peripheral IV every time. Yes, you can usually see or feel a bump.

PR / PR+

Progesterone receptor
Pathology
The medical version

A biomarker indicating whether breast-cancer cells contain receptors for progesterone.

Babette translates

Another hormone-receptor result on the pathology report. Your doctors interpret it alongside ER, HER2 and other features of the tumor.

Recurrence

Cancer returning
Cancer language
The medical version

Cancer that returns after a period in which it was not detected. Recurrence can be described as local, regional or distant.

Babette translates

“Cancer came back” can mean different things depending on where it returned. Local, regional and distant recurrence are not interchangeable, so ask exactly what your team means.

Radiation therapy

Radiotherapy
Radiation
The medical version

Cancer treatment using high-energy radiation to damage cancer cells in a targeted area.

Babette translates

A local treatment aimed at a specific part of the body. Unlike chemotherapy and other systemic treatments, it isn't circulating through your whole body.

Radiation simulation

Sim · Simulation · Planning appointment
Radiation
The medical version

A treatment-planning session used to determine positioning and map the area to be treated before radiation begins.

Babette translates

This is the setup appointment before the actual radiation treatments. Your team is figuring out exactly how you'll be positioned and how to aim treatment accurately.

If someone called it “mapping”: This may be what they meant.

Sentinel lymph node

Sentinel node · SLN
Surgery + staging
The medical version

The first lymph node or group of nodes expected to receive lymphatic drainage from the area of a tumor.

Babette translates

Think of these as the first lymph-node checkpoint. Surgeons can examine them for cancer rather than automatically removing a larger group of nodes in every situation.

Seroma

Postoperative fluid collection
Recovery
The medical version

A collection of clear fluid that can accumulate in tissue after surgery.

Babette translates

That fluid pocket or sloshy swelling after surgery may be a seroma. Don't decide what it is from the internet—show or describe new postoperative swelling to your surgical team.

Somatic mutation

Tumor-acquired mutation
Genetics + genomics
The medical version

A genetic change acquired in body or tumor cells rather than inherited through the germline.

Babette translates

A mutation found in the cancer is not automatically something you were born with or something your children can inherit. That's why “genetic” and “genomic” conversations can get confusing.

Stage

Stage 0 · I · II · III · IV
Staging
The medical version

A system used to describe the extent and characteristics of cancer. Breast-cancer staging can incorporate tumor size, regional lymph nodes, distant metastasis and, in prognostic staging, biological features of the tumor.

Babette translates

Stage helps your team describe the overall cancer picture. It is not simply another word for “how aggressive.”

Stage vs. grade: Stage and grade answer different questions. Don't let the fact that both use numbers trick you into combining them.

Tamoxifen

Endocrine therapy · SERM
Medication
The medical version

A selective estrogen receptor modulator used in certain hormone receptor-positive breast cancers and in some risk-reduction settings.

Babette translates

A medication that interferes with estrogen signaling in breast tissue. If your cancer is hormone receptor-positive, you may hear this name early and often.

Targeted therapy

Targeted cancer treatment
Treatment
The medical version

Treatment designed to act on specific molecules or biological pathways involved in cancer growth or survival.

Babette translates

Instead of describing treatment only by where the cancer is, targeted therapy goes after a particular feature or pathway the cancer depends on.

Triple-negative breast cancer

TNBC
Diagnosis
The medical version

Breast cancer classified as negative for estrogen receptor, progesterone receptor and HER2 according to applicable testing criteria.

Babette translates

The “triple” is ER, PR and HER2. Those three common treatment targets aren't positive in TNBC, so your team plans treatment using other features of the cancer and your situation.

Breast ultrasound

Sonogram
Imaging
The medical version

Imaging that uses sound waves to create pictures of structures inside the breast.

Babette translates

Gel, a handheld probe and sound waves. No x-rays. It can help your team look more closely at a specific area.

We don't know that one yet.

Which probably means we should. Try another spelling, a brand name, a nickname or just describe what you heard. We're building this around the language people actually encounter—not only the words doctors use.

Sources + medical note

We translate the medical terms. We show our work.

Babette translates medical language into plain English so you can better understand your care and ask informed questions. Our definitions are developed using medical, academic and public-health sources.

Medicine changes. Treatment eligibility, terminology and recommendations can change as new evidence emerges. This dictionary is educational and is not a substitute for individualized medical advice, diagnosis or treatment. Your own pathology, imaging, medications and treatment plan should be interpreted with your healthcare team.

Centers for Disease Control and Prevention Diagnosing Breast Cancer ↗
National Institutes of Health Understanding Breast Cancer ↗
National Cancer Institute NCI Dictionary of Cancer Terms ↗

Source library reviewed October 2026.