The Babette Dictionary
What does that mean?
Breast cancer comes with a language nobody teaches you. Search the thing your doctor said, the phrase in your pathology report or the nickname somebody dropped in the infusion room.
You don't need to know the medical term. We'll help with that part.
Try normal-person language: “cancer in my armpit,” “chemo before surgery,” “radiation mapping,” “estrogen positive.”
Look it up
The words they keep using, in words you actually understand.
AC chemotherapy
AC is a breast-cancer chemotherapy regimen containing doxorubicin and cyclophosphamide.
The A is Adriamycin, another name for doxorubicin. The C is cyclophosphamide. If someone says you're “doing AC,” they're talking about this combination.
Adjuvant therapy
Treatment given after the primary treatment, often surgery, to reduce the risk of cancer returning.
Treatment that comes after the main event—usually surgery—to deal with cancer cells that could remain or lower the chance of the cancer coming back.
Aesthetic flat closure
A surgical approach after mastectomy in which excess skin, fat and tissue are arranged or removed to create a smooth, flat chest contour rather than a breast mound.
You can have a mastectomy and choose not to reconstruct a breast shape. “Going flat” is a real surgical choice—not a failure to finish reconstruction.
Amplification
An increase in the number of copies of a particular gene within a cell.
The cancer cells have extra copies of a gene. In breast cancer, you may hear this when your team is figuring out HER2 status.
Aromatase inhibitor
A class of endocrine therapy that lowers estrogen production by blocking the aromatase enzyme.
If estrogen helps your cancer grow, this is one way doctors can turn down the body's estrogen supply.
Axilla
The anatomical term for the underarm area. Several groups of lymph nodes important in breast-cancer staging are located there.
Your armpit. Seriously. That's the fancy word.
Axillary lymph node dissection
Surgery to remove multiple lymph nodes from the axilla so they can be examined for cancer.
Instead of removing only the first few sentinel nodes, the surgeon removes a larger group of lymph nodes from your underarm.
BI-RADS
A standardized system radiologists use to categorize breast imaging findings and communicate recommended follow-up.
It's a category on your imaging report that helps explain what the radiologist saw and what should happen next.
Biomarker
A measurable biological characteristic that can provide information about a cancer, including prognosis or whether a particular treatment may be useful.
A clue your doctors can measure. ER, PR and HER2 are examples you'll hear about a lot because they can help shape treatment.
Biopsy
A procedure that removes cells or tissue so a pathologist can examine them for disease.
Imaging can show that something looks suspicious. A biopsy gets actual cells or tissue so someone can determine what that thing really is.
BRCA1 + BRCA2
Genes involved in DNA repair. Certain inherited harmful variants in BRCA1 or BRCA2 increase the risk of breast and other cancers.
Everyone has BRCA genes. The question is whether you inherited a harmful change in one of them that changes your cancer risk.
Breast density
A description of the relative amount of fibroglandular tissue and fatty tissue visible on a mammogram.
Dense breasts have more glandular and fibrous tissue relative to fat. Density can make mammograms harder to read and is also one factor considered in breast-cancer risk.
Calcifications
Calcium deposits visible on breast imaging. Many patterns are benign, while some patterns may require additional evaluation.
Tiny calcium spots on a mammogram. Seeing them does not automatically mean cancer. The pattern, size and arrangement are part of what the radiologist evaluates.
Chemotherapy
Treatment using anticancer drugs that can travel through the body to destroy cancer cells or interfere with their growth.
Cancer-fighting medicine that works throughout the body, rather than treating only the breast or one specific spot.
Scalp cooling
Cooling of the scalp before, during and sometimes after chemotherapy to reduce blood flow to hair follicles and help reduce chemotherapy-related hair loss in some people.
The very cold cap you've probably heard about. The goal is to help preserve some hair during certain chemotherapy treatments. It doesn't work the same way for everyone or every regimen.
Axillary web syndrome
A postoperative condition in which tight, cord-like structures can develop under the skin of the axilla and sometimes extend down the arm.
That tight string or cord you can sometimes see or feel in your armpit or arm after breast or lymph-node surgery has a name. Tell your care team; rehabilitation or physical therapy may help.
DCIS
Abnormal cells confined to the breast ducts that have not invaded surrounding breast tissue.
The abnormal cells are inside a milk duct, but they haven't broken through the duct wall into the surrounding breast tissue.
Diagnostic mammogram
Mammography used to evaluate a breast symptom or an area of concern identified on screening.
This isn't the routine screening version. They're taking a closer look at a specific area because there's something they want to understand better.
Doxorubicin
Doxorubicin is an anthracycline chemotherapy drug used in the treatment of several cancers, including breast cancer.
This is the bright red chemotherapy drug people sometimes call the “Red Devil.” That's a nickname. The actual drug is doxorubicin, also known as Adriamycin.
Endocrine therapy
Treatment that blocks hormones or lowers hormone levels to interfere with the growth of hormone receptor-positive cancer.
If hormones such as estrogen are helping the cancer grow, endocrine therapy tries to interrupt that relationship.
ER / ER+
A biomarker indicating whether breast-cancer cells contain receptors for estrogen.
They're checking whether estrogen can act like a growth signal for the cancer. If the tumor is ER-positive, treatments that interfere with estrogen may be part of your plan.
FISH
A laboratory technique that can evaluate gene changes such as HER2 gene amplification in tumor tissue.
If someone says they're doing a “FISH test,” nobody is testing an actual fish. It's a lab test that can help clarify HER2 status by looking at copies of the HER2 gene.
Germline mutation
A genetic change present in the egg or sperm and therefore present throughout the body; it can potentially be passed from parent to child.
This is the kind of genetic change you can be born with and potentially pass through a family. It is different from a mutation found only in the tumor.
Grade
A microscopic assessment of how much cancer cells differ from normal breast cells. Breast tumor grade commonly incorporates gland formation, nuclear features and mitotic activity.
Grade is about what the cancer looks like under the microscope and features related to how it's growing. It is not the same thing as stage.
HER2
HER2 is a growth-related protein. Breast cancers are evaluated for HER2 because the result can help classify the cancer and guide treatment.
Your team is measuring a growth-related target on the cancer. That result matters because certain treatments are designed to target HER2.
IHC
A laboratory method using antibodies to detect specific proteins in tissue.
A special lab stain that helps the pathologist see whether certain proteins are present in the tumor—and sometimes how strongly they're showing up.
Invasive
Cancer is called invasive when it has grown beyond the structure where it began and into surrounding breast tissue.
This word sounds terrifying. What it tells you is that the cancer has moved into nearby breast tissue. It does not automatically mean the cancer has spread to a distant part of your body.
Invasive ductal carcinoma
Breast cancer that began in a duct and has grown into surrounding breast tissue.
It started in a milk duct and crossed beyond that duct into nearby breast tissue. Again: “invasive” does not automatically mean distant spread.
Invasive lobular carcinoma
An invasive breast cancer arising from cells associated with the breast lobules.
This breast cancer is associated with the milk-producing lobules rather than being classified as ductal.
Ki-67
A protein associated with cell division that can be measured to estimate the proportion of tumor cells actively proliferating.
One clue about how many tumor cells appear to be actively dividing. It's a piece of the picture—not a diagnosis by itself.
LCIS
A proliferation of abnormal cells within breast lobules that is associated with an increased risk of developing invasive breast cancer.
Despite the alarming name, LCIS behaves differently from invasive breast cancer. It's an important finding because it tells your team something about future breast-cancer risk.
Lymph node
Small immune-system structures that filter lymphatic fluid. Nearby lymph nodes may be examined for breast-cancer cells.
Your team may check the lymph nodes near the breast because they can provide important information about whether cancer cells have moved beyond the original breast tumor.
Lymphovascular invasion
Cancer cells identified within lymphatic or blood-vessel spaces in or around a tumor.
The pathologist saw cancer cells inside tiny channels that carry lymph or blood. Your team considers this finding alongside the rest of your pathology—not in isolation.
Lymphedema
Swelling caused by an accumulation of lymphatic fluid when normal lymph drainage is disrupted.
Breast-cancer surgery or radiation can affect lymph drainage. If you notice new or persistent swelling, heaviness or tightness, tell your care team rather than trying to diagnose it yourself.
Mammogram
A specialized low-dose x-ray examination of breast tissue.
The breast x-ray where each breast is positioned and compressed so the radiologist can look for changes that may need a closer look.
Margins
The edges of tissue removed during surgery. A pathologist examines those edges for cancer cells.
After tissue is removed, the pathologist checks the outer edges. Your team wants to know whether cancer reaches the edge of what was taken out.
Mastectomy
Surgery to remove breast tissue. Different mastectomy techniques remove or preserve different structures depending on the clinical and reconstructive plan.
“Mastectomy” is a category, not one single operation. Ask exactly what your surgeon plans to remove, what may be preserved and what your chest is expected to look like afterward.
Metastatic breast cancer
Breast cancer that has spread from the breast to a distant part of the body.
This means breast-cancer cells are growing somewhere distant from the breast—such as bone, liver, lung or brain. Cancer in nearby breast tissue or regional lymph nodes is not the same thing as distant metastasis.
Mitotic count
A microscopic assessment of how many cells are visibly undergoing division in a defined area.
The pathologist is literally looking for cells caught in the act of dividing. It's one of the features that can contribute to breast tumor grade.
Breast MRI
Imaging that uses a magnetic field and radio waves to create detailed pictures of breast tissue.
A detailed breast scan made with magnets and radio waves, not x-rays. Whether you need one depends on why your team is imaging you.
Neoadjuvant therapy
Cancer treatment given before surgery. Depending on the cancer, this may include chemotherapy, targeted therapy or other systemic treatment.
They're treating the cancer before operating instead of automatically doing surgery first.
NED
A phrase used when current examinations or tests do not detect evidence of cancer.
At this moment, the tests being used aren't showing detectable disease. Ask your team what NED means in the context of your specific diagnosis and follow-up plan.
Peripheral neuropathy
Damage or irritation involving peripheral nerves that can cause numbness, tingling, burning, pain or other sensory changes. Some cancer treatments can cause peripheral neuropathy.
If your fingers or toes start tingling, burning, feeling numb or just feeling wrong during treatment, don't quietly tough it out. Tell your oncology team.
Pegfilgrastim
A long-acting form of granulocyte colony-stimulating factor used to help the bone marrow produce more white blood cells and reduce infection risk associated with chemotherapy-induced neutropenia.
This may be the “white blood cell shot” or “shot after chemo” someone mentioned. It helps your bone marrow make more infection-fighting white blood cells.
Nuclear grade
A microscopic assessment of how abnormal the nuclei of tumor cells appear compared with normal cells.
The pathologist is looking closely at the control centers of the cells—the nuclei—and judging how different they look from normal.
Oncotype DX
A genomic assay used in certain breast cancers that analyzes gene activity in tumor tissue and produces a recurrence score that can help inform treatment decisions.
This is a test on the tumor. It is not the same thing as testing whether you inherited a breast-cancer gene. In eligible cancers, the result can help inform decisions about chemotherapy.
Palliative care
Specialized care focused on relieving symptoms, treatment side effects and other sources of distress associated with serious illness.
Palliative care is about helping you feel and function as well as possible while dealing with serious illness. It is not synonymous with hospice, and it can be provided alongside cancer treatment.
Pathology report
A report prepared after a pathologist examines cells or tissue. Depending on the specimen, it can contain information about cancer type, grade, biomarkers, margins, lymph nodes and other findings.
This is one of the documents where the details of your cancer start coming together. And yes, it often reads like it was written for everyone except you.
Port
A small implanted vascular-access device connected to a catheter and placed under the skin, often in the upper chest.
A small device under your skin that gives the infusion team reliable access to a vein without starting a new peripheral IV every time. Yes, you can usually see or feel a bump.
PR / PR+
A biomarker indicating whether breast-cancer cells contain receptors for progesterone.
Another hormone-receptor result on the pathology report. Your doctors interpret it alongside ER, HER2 and other features of the tumor.
Recurrence
Cancer that returns after a period in which it was not detected. Recurrence can be described as local, regional or distant.
“Cancer came back” can mean different things depending on where it returned. Local, regional and distant recurrence are not interchangeable, so ask exactly what your team means.
Radiation therapy
Cancer treatment using high-energy radiation to damage cancer cells in a targeted area.
A local treatment aimed at a specific part of the body. Unlike chemotherapy and other systemic treatments, it isn't circulating through your whole body.
Radiation simulation
A treatment-planning session used to determine positioning and map the area to be treated before radiation begins.
This is the setup appointment before the actual radiation treatments. Your team is figuring out exactly how you'll be positioned and how to aim treatment accurately.
Sentinel lymph node
The first lymph node or group of nodes expected to receive lymphatic drainage from the area of a tumor.
Think of these as the first lymph-node checkpoint. Surgeons can examine them for cancer rather than automatically removing a larger group of nodes in every situation.
Seroma
A collection of clear fluid that can accumulate in tissue after surgery.
That fluid pocket or sloshy swelling after surgery may be a seroma. Don't decide what it is from the internet—show or describe new postoperative swelling to your surgical team.
Somatic mutation
A genetic change acquired in body or tumor cells rather than inherited through the germline.
A mutation found in the cancer is not automatically something you were born with or something your children can inherit. That's why “genetic” and “genomic” conversations can get confusing.
Stage
A system used to describe the extent and characteristics of cancer. Breast-cancer staging can incorporate tumor size, regional lymph nodes, distant metastasis and, in prognostic staging, biological features of the tumor.
Stage helps your team describe the overall cancer picture. It is not simply another word for “how aggressive.”
Tamoxifen
A selective estrogen receptor modulator used in certain hormone receptor-positive breast cancers and in some risk-reduction settings.
A medication that interferes with estrogen signaling in breast tissue. If your cancer is hormone receptor-positive, you may hear this name early and often.
Targeted therapy
Treatment designed to act on specific molecules or biological pathways involved in cancer growth or survival.
Instead of describing treatment only by where the cancer is, targeted therapy goes after a particular feature or pathway the cancer depends on.
Triple-negative breast cancer
Breast cancer classified as negative for estrogen receptor, progesterone receptor and HER2 according to applicable testing criteria.
The “triple” is ER, PR and HER2. Those three common treatment targets aren't positive in TNBC, so your team plans treatment using other features of the cancer and your situation.
Breast ultrasound
Imaging that uses sound waves to create pictures of structures inside the breast.
Gel, a handheld probe and sound waves. No x-rays. It can help your team look more closely at a specific area.
We don't know that one yet.
Which probably means we should. Try another spelling, a brand name, a nickname or just describe what you heard. We're building this around the language people actually encounter—not only the words doctors use.
Sources + medical note
We translate the medical terms. We show our work.
Babette translates medical language into plain English so you can better understand your care and ask informed questions. Our definitions are developed using medical, academic and public-health sources.
Medicine changes. Treatment eligibility, terminology and recommendations can change as new evidence emerges. This dictionary is educational and is not a substitute for individualized medical advice, diagnosis or treatment. Your own pathology, imaging, medications and treatment plan should be interpreted with your healthcare team.
Source library reviewed October 2026.